Results with Rituxan

Rituxan is the first and only FDA-approved therapy that can help control a flare and put your disease into remission. Talk with your doctor to see if Rituxan may be right for you.

Proven to put GPA and MPA into complete remission

The Rituximab in ANCA-Associated Vasculitis (RAVE) trial was conducted with support from the National Institute of Allergy and Infectious Diseases and the Immune Tolerance Network to see if Rituxan worked as well as cyclophosphamide in bringing on complete remission* in adults with Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA).

The RAVE trial showed that 64% of people taking Rituxan achieved complete remission by 6 months and that Rituxan worked just as well as cyclophosphamide, the standard of care. In addition, there were no major differences between the overall side effects of Rituxan and cyclophosphamide.

Common side effects of Rituxan include infections, nausea, diarrhea, headache, muscle spasms, anemia, and peripheral edema (swollen hands and feet). Other more serious side effects may include serious infections, progressive multifocal leukoencephalopathy (PML), severe infusion reactions, tumor lysis syndrome (TLS), and severe skin reactions.

*
In this trial, "complete remission" was defined as no disease activity and no need for steroid therapy.

WHAT IS RITUXAN?

Rituxan® (rituximab) is used with glucocorticoids to treat adults with Granulomatosis with Polyangiitis (GPA) (Wegener's Granulomatosis) and Microscopic Polyangiitis (MPA).

IMPORTANT SAFETY INFORMATION

Rituxan therapy can result in serious side effects, some of which can be life threatening. These include:

  • infusion reactions
  • tumor lysis syndrome (TLS)
  • severe skin and mouth reactions
  • progressive multifocal leukoencephalopathy (PML)

Other serious, potentially life-threatening side effects are:

  • hepatitis B infection that may become active again
  • serious infections
  • heart problems
  • low blood cell counts

Common side effects include infections and infusion reactions.

Before treatment with Rituxan, patients should tell their doctor if they have an infection, including one that will not go away or that keeps coming back.

If patients experience any symptoms or side effects during or after Rituxan treatment, they should seek immediate medical attention.

These are not all of the possible side effects with Rituxan. Tell your doctor about any side effect that bothers you or that does not go away.

Please see full prescribing information, including Medication Guide.

If you have any questions about this information, be sure to discuss them with your doctor.