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THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT RITUXAN: INFUSION REACTIONS, SEVERE SKIN AND MOUTH REACTIONS, HEPATITIS B VIRUS (HBV) REACTIVATION AND PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML)

Prescribing Information

Resources and support

RITUXAN Patient Assistance Programs

Genentech Access Solutions®—Connecting patients to RITUXAN
Even if you have health insurance, you might feel concerned about the cost of your treatment. There may be assistance for people taking Genentech medicines who have:

To contact Genentech Access Solutions:

The Genentech BioOncology® Co-pay Card
Genentech offers the Genentech BioOncology Co-pay Card that may help you with the out-of-pocket costs of RITUXAN.*

*The Genentech BioOncology Co-pay Card is available only for commercially insured patients. Patients using Medicare, Medicaid or any other government funded program to pay for their medications are not eligible. It requires a valid, on-label prescription and cannot be combined with any other rebate/coupon, free trial or similar offer for the specified prescription. It is available only for a patient (or their guardian) who is 18 years or older. It is not valid for medications the patient receives for free or that are eligible to be reimbursed by private insurance plans or other health care or pharmaceutical assistance programs that reimburse the patient in whole or in part for the medication. It is valid only for Genentech products in the United States and Puerto Rico. The Genentech BioOncology Co-pay Card is not health insurance or a benefit plan.

Please see full terms and conditions at www.copayassistancenow.com/#/rituxan/copay-card.

Genentech Access Solutions: Commitment to Patient Access
Genentech Access Solutions is a program that helps people who are taking RITUXAN. Your health insurance plan and the cost of your medicine might keep you from getting your prescribed treatment. We may be able to help. To learn more about Genentech Access Solutions, call (888) 249-4918 or visit Genentech-Access.com/RITUXAN.

Genentech® Access to Care Foundation (GATCF)
GATCF helps people who don’t have health insurance. It also helps people who have health insurance but have trouble paying for RITUXAN. If you qualify for GATCF, you could receive RITUXAN free of charge. Visit Genentech Access to Care Foundation for more information.

Rituxan is available by prescription only.

INDICATIONS

RITUXAN® (rituximab) is indicated for the treatment of: 

  • Low-grade or follicular CD20-positive Non-Hodgkin's lymphoma as a single-agent therapy in patients whose disease recurred or did not respond to initial treatment
  • Follicular CD20-positive Non-Hodgkin's lymphoma as an initial treatment with chemotherapy, and in patients whose initial treatment was successful, as a single-agent follow-up therapy
  • Low-grade CD20-positive Non-Hodgkin's lymphoma as a single agent follow-up therapy for patients who did not progress on initial treatment with CVP chemotherapy
  • CD20-positive diffuse large B-cell Non-Hodgkin's lymphoma as an initial treatment in combination with CHOP chemotherapy
  • CD20-positive chronic lymphocytic leukemia in combination with FC chemotherapy as an initial treatment or as a treatment after disease has recurred

People with serious infections should not receive RITUXAN.

It is not known if RITUXAN is safe or effective in children.

Important Safety Information

What is the most important information I should know about RITUXAN? 

Tell your doctor right away about any side effect you experience. RITUXAN can cause serious side effects that can lead to death, including: 

  • Infusion Reactions: may occur during or within 24 hours of your infusion. Your doctor should give you medicines before your treatment. Symptoms can include hives, rash, itching, facial or oral swelling, sudden cough, shortness of breath, difficulty breathing, weakness, dizziness, feeling faint, racing heart, or chest pain 
  • Severe Skin and Mouth Reactions: symptoms can include painful sores, ulcers, or blisters on your skin, lips or mouth; peeling skin; rash; or pustules 
  • Hepatitis B Virus (HBV) Reactivation: may cause serious liver problems including liver failure and death. If you have had hepatitis B or are a carrier of HBV, receiving RITUXAN could cause the virus to become an active infection again. You should not receive RITUXAN if you have active HBV liver disease. Your doctor will do blood tests to check for HBV infection prior to treatment and will monitor you during and for several months following your treatment 
  • Progressive Multifocal Leukoencephalopathy (PML): a rare, serious brain infection that can lead to severe disability and death and for which there is no known prevention, treatment, or cure. Symptoms can include difficulty thinking, loss of balance, changes in speech or walking, weakness on one side of your body, or blurred or lost vision 

What are the additional possible serious side effects of RITUXAN? 

Tell your doctor right away about any side effect you experience. RITUXAN can cause serious side effects that can lead to death, including: 

  • Tumor Lysis Syndrome (TLS): may cause kidney failure and the need for dialysis treatment, abnormal heart rhythm, and can lead to death. Your doctor may give you medicines before your treatment to help prevent TLS 
  • Serious Infections: can happen during and after treatment and can lead to death. These infections may be bacterial, fungal, or viral. Symptoms can include fever; cold or flu symptoms; earache or headache; pain during urination; white patches in the mouth or throat; cuts or scrapes that are red, warm, swollen, or painful 
  • Heart Problems: symptoms can include chest pain and irregular heartbeats that may require treatment. Your doctor may need to stop your treatment 
  • Kidney Problems: your doctor should do blood tests to check how well your kidneys are working 
  • Stomach and Serious Bowel Problems: can include blockage or tears in the bowel that can lead to death. Stomach area pain during treatment can be a symptom 
  • Low Blood Cell Counts: your blood cell counts may be monitored during treatment 

The most common side effects of RITUXAN are infusion reactions, chills, infections, body aches, tiredness, and low white blood cells. 

Other side effects with RITUXAN include:

  • aching joints during or within hours of receiving an infusion 
  • more frequent upper respiratory tract infection

Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if RITUXAN may harm your unborn baby or pass into your breast milk. Women should use birth control while using RITUXAN and for 12 months after treatment.

Tell your doctor about any side effect that bothers you or that does not go away.

These are not all of the possible side effects of RITUXAN. For more information, ask your doctor or pharmacist.

Please see the RITUXAN full Prescribing Information, including the Medication Guide, for additional important safety information.

You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch.

You may also report side effects to Genentech at (888) 835-2555.

THIS INFORMATION DOES NOT TAKE THE PLACE OF TALKING WITH YOUR DOCTOR. DISCUSS WITH YOUR DOCTOR ANY QUESTIONS YOU HAVE ABOUT YOUR MEDICAL CONDITION OR YOUR TREATMENT.