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Rituxan selectively targets only CD20+ B cells²—not the entire immune system

CD20 is not found on stem cells, pro-B cells, normal plasma cells, or other normal tissues²

B-cells are believed to contribute to the immune processes that lead to inflammation and joint damage²

Potential roles of the immune process in the pathogenesis of RA

B cells are implicated in the production of cytokines¹⁶

• IL-1, TNF, IL-6

Osteoclast activity and bone erosion

• In some models, IL-1, TNF, and IL-6, as well as other factors, enhance RANKL
• RANKL mediates osteoclastogenesis

Also in this section:

Learn about the role of B cells in RA

 

Next The Role of B Cells in RA

REFERENCES

2.	Rituxan [package insert]. South San Francisco, CA: Biogen Idec, Inc. and Genentech, Inc.; 2007.
16.	Lund FE, Garvy BA, Randall TD, Harris DP. Regulatory roles for cytokine-producing B cells in infection and autoimmune disease. Curr Dir Autoimmun. 2005;8:25-54.