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  <ul xmlns:nav="http://www.meltmedia.com/navigation/1.0" class="level1"><li class=""><a class=" " href="/ra/hcp/index.html">Rheumatoid Arthritis Treatment</a></li><li class=""><a class=" " href="/ra/hcp/about/index.html">Rituxan Clinical Data</a><ul class="level2"><li class=""><a class="  " href="/ra/hcp/about/pivotal-data/index.html#pivotal-data">REFLEX Trial: End Points</a><ul class="level3"><li class=""><a class="  " href="/ra/hcp/about/pivotal-data/index.html#reflex-trial-primary-endpoint">Reflex Trial: Primary End Point</a></li><li class=""><a class="  " href="/ra/hcp/about/pivotal-data/index.html#effective-dosing-video">Patient Case History: Effective Dosing at 6-Month Intervals</a></li><li class=""><a class="  " href="/ra/hcp/about/pivotal-data/index.html#reflex-trial-secondary-endpoint">Reflex Trial: Secondary End Point</a></li></ul></li><li class=""><a class="  " href="/ra/hcp/about/safety-data/index.html#safety-data">Clinical Trial Safety Data</a><ul class="level3"><li class=""><a class="  " href="/ra/hcp/about/safety-data/index.html#adverse-reactions">Common Adverse Events</a></li><li class=""><a class="  " href="/ra/hcp/about/safety-data/index.html#infusion-reactions">Infusion Reactions</a></li><li class=""><a class="  " href="/ra/hcp/about/safety-data/index.html#infection-data">Infection Data</a></li></ul></li><li class=""><a class="  " href="/ra/hcp/about/radiographic-data/index.html#radiographic-data">REFLEX Trial: Radiographic Data</a></li><li class=""><a class="  " href="/ra/hcp/about/efficacy-over-multiple-courses/index.html#efficacy-over-multiple-courses">Efficacy Over Multiple Courses</a><ul class="level3"><li class=""><a class="  " href="/ra/hcp/about/efficacy-over-multiple-courses/index.html#sustained-efficacy-video">Patient Case History: Sustained Efficacy Over Multiple Courses</a></li></ul></li><li class=""><a class="  " href="/ra/hcp/about/how-rituxan-works/index.html#how-rituxan-works">How Rituxan Works</a><ul class="level3"><li class=""><a class="  " href="/ra/hcp/about/how-rituxan-works/index.html#b-cells">Role of B Cells</a></li><li class=""><a class="  " href="/ra/hcp/about/how-rituxan-works/index.html#mechanism-of-action-of-rituxan">MOA</a></li><li class=""><a class="  " href="/ra/hcp/about/how-rituxan-works/index.html#rituxan-works-video">How Rituxan Works: MOA</a></li></ul></li><li class=""><a class="  " href="/ra/hcp/about/important-safety-information/index.html#important-safety-information">Important Safety Information</a></li><li class=""><a class="  " href="/ra/hcp/about/registry-data/index.html#registry-data">Patient Selection Registry Data</a><ul class="level3"><li class=""><a class="  " href="/ra/hcp/about/registry-data/index.html#tnfi-video">Switching TNFi Patients to Subsequent MOA</a></li></ul></li></ul></li><li class=""><a class=" " href="/ra/hcp/dosing/index.html">Dosing and Administration</a><ul class="level2"><li class=""><a class="  " href="/ra/hcp/dosing/dosing-and-administration/index.html#dosing-and-administration">Administering Rituxan</a><ul class="level3"><li class=""><a class="  " href="/ra/hcp/dosing/dosing-and-administration/index.html#effective-dosing-video">Patient Case History: Effective Dosing at 6-Month Intervals</a></li></ul></li></ul></li><li class=""><a class=" " href="/ra/hcp/safety/index.html">Safety Profile</a><ul class="level2"><li class=""><a class="  " href="/ra/hcp/safety/important-safety-information/index.html#important-safety-information">Important Safety Information</a></li><li class=""><a class="  " href="/ra/hcp/safety/infusion-reactions/index.html#infusion-reactions">Infusion Reactions</a><ul class="level3"><li class=""><a class="  " href="/ra/hcp/safety/infusion-reactions/index.html#pivotal">Pivotal</a></li><li class=""><a class="  " href="/ra/hcp/safety/infusion-reactions/index.html#van-vollenhoven">Van Vollenhoven</a></li><li class=""><a class="  " href="/ra/hcp/safety/infusion-reactions/index.html#long-term-video">Long-Term Safety From ACR 2009</a></li></ul></li><li class=""><a class="  " href="/ra/hcp/safety/infections/index.html#infections">Infections</a><ul class="level3"><li class=""><a class="  " href="/ra/hcp/safety/infections/index.html#pivotal">Pivotal</a></li><li class=""><a class="  " href="/ra/hcp/safety/infections/index.html#van-vollenhoven">Van Vollenhoven</a></li><li class=""><a class="  " href="/ra/hcp/safety/infections/index.html#long-term-video">Long-Term Safety From ACR 2009</a></li></ul></li><li class=""><a class="  " href="/ra/hcp/safety/post-safety/index.html#post-safety">Post-Rituxan Safety</a><ul class="level3"><li class=""><a class="  " href="/ra/hcp/safety/post-safety/index.html#b-cell-video">Safety of Biologics in B-Cell Depleted Patients</a></li></ul></li></ul></li></ul>
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  <h4>INDICATION</h4>

  <p>Rituxan (rituximab) in combination with methotrexate is indicated for the treatment of adult patients with moderately to severely- active rheumatoid arthritis who have had an inadequate response to one or more TNF antagonist therapies.</p>

  <p>Rituxan is not recommended for treatment of patients with severe active infections.</p>

  <h4>IMPORTANT SAFETY INFORMATION</h4>
  <p><strong>BOXED WARNINGS</strong></p>

  <p><strong>Rituxan administration can result in serious, including fatal, adverse reactions. These include:</strong></p>
	
	<ul>
		<li><strong>infusion reactions</strong></li>
		<li><strong>tumor lysis syndrome (TLS)</strong></li>
		<li><strong>severe mucocutaneous reactions</strong></li>
		<li><strong>progressive multifocal leukoencephalopathy (PML)</strong></li>	
	</ul>

  <h4>WARNINGS AND PRECAUTIONS</h4>

  <p>Rituxan administration can also result in additional serious, including fatal, adverse reactions including: </p>
	<ul>
		<li>hepatitis B reactivation</li>
		<li>other infections including bacterial, fungal, new or reactivated viral infections</li>
		<li>cardiovascular events</li>
	</ul>
	
  <p>Patients should be closely observed for signs of infection if biologic agents and /or DMARDs other than methotrexate are used concomitantly.</p>

  <p>Common adverse reactions include infusion reactions and infections.</p>

  <p><em>For additional safety information, please see the full <a title="Prescribing information and medication guide" target="_blank" href="http://www.gene.com/gene/products/information/pdf/rituxan-prescribing.pdf">prescribing information</a>, including <strong>BOXED WARNINGS</strong> and Medication Guide.</em></p>
  
  <p><em><strong>Attention Healthcare Provider: Provide Medication Guide to patient prior to Rituxan infusion.</strong></em></p>
  
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