Dosage and Administration
Rituxan has a familiar infusion setup that is similar to other IVs your staff administers
Rituxan is given in combination with methotrexate2
- Rituxan is administered as two 1000-mg IV infusions separated by 2 weeks
- Glucocorticoids, administered as methylprednisolone 100 mg IV or its equivalent 30 minutes prior to each infusion, are recommended to reduce the incidence and severity of infusion reactions
- The use of oral glucocorticoids provides no additional safety benefits
- Premedication with acetaminophen and an antihistamine should be considered before each infusion of Rituxan
A Rituxan nurse can help train you and your staff prior to the first few Rituxan infusions.
For full instructions on dosage and administration, please see the DOSAGE AND ADMINISTRATION section of the full prescribing information.
Dosing schedules of selected biologic RA therapies
Please see respective prescribing information for dosing considerations for each product. All trademarks are the property of their respective owners. Data derived from full prescribing information for Enbrel,11 Humira,12 Orencia,13 Remicade,14 and Rituxan.2
No conclusions regarding comparative safety or efficacy between products can be drawn from comparing their dosing schedules.
RITUXAN (Rituximab) in combination with methotrexate is indicated to reduce signs and symptoms and to slow the progression of structural damage in adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more TNF antagonist therapies.
Safety and efficacy of retreatment with Rituxan have not been established in controlled trials.
