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WHAT IS RITUXAN?

Rituxan is a prescription medicine used in adults with another medicine called methotrexate to reduce the signs and symptoms of moderately to severely active rheumatoid arthritis (RA) after at least one other medicine called a tumor necrosis factor (TNF) antagonist has been used and did not work well.

People with serious infections should not receive Rituxan.

IMPORTANT SAFETY INFORMATION

Rituxan therapy can result in serious side effects, some which can be life-threatening. These include infusion reactions, tumor lysis syndrome (TLS), severe mucocutaneous reactions, and progressive multifocal leukoencephalopathy (PML). Other serious, potentially life threatening side effects are: hepatitis B infection that may become active again, serious infections, heart problems and low blood cell counts.

Common side effects include infections and infusion reactions.

Before treatment with Rituxan, patients should tell their doctor if they have an infection, including one that will not go away or keeps coming back.

If patients experience any symptoms or side effects during or after Rituxan treatment, they should seek immediate medical attention.

For additional important safety information please see the Rituxan full Prescribing Information, including BOXED WARNINGS and Medication Guide.

What to Expect With Treatment

Rituxan^® (rituximab) is given as an intravenous (IV) infusion, along with methotrexate. One course of treatment requires 2 separate IV infusions given 2 weeks apart.

Infusion reactions are the most common side effect of Rituxan treatment. Serious infusion reactions can happen during your infusion or within 24 hours after your infusion of Rituxan. Your doctor should give you medicines before your infusion of Rituxan to decrease your chance of having a severe infusion reaction.

For important safety information about Rituxan, including possible infusion reactions, please see the Rituxan full Prescribing Information, including Medication Guide.

Dosing Schedules for a Variety of Biologic Treatments

Dosing Schedule

Please see respective prescribing information for dosing considerations for each product. All trademarks are the properties of their respective owners. Data derived from full prescribing information for Rituxan, Remicade, Orencia, Simponi, Cimzia, Humira and Enbrel.