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WHAT IS RITUXAN?

Rituxan is a prescription medicine used in adults with another medicine called methotrexate to reduce the signs and symptoms of moderately to severely active rheumatoid arthritis (RA) after at least one other medicine called a tumor necrosis factor (TNF) antagonist has been used and did not work well.

People with serious infections should not receive Rituxan.

IMPORTANT SAFETY INFORMATION

Rituxan therapy can result in serious side effects, some which can be life-threatening. These include infusion reactions, tumor lysis syndrome (TLS), severe mucocutaneous reactions, and progressive multifocal leukoencephalopathy (PML). Other serious, potentially life threatening side effects are: hepatitis B infection that may become active again, serious infections, heart problems and low blood cell counts.

Common side effects include infections and infusion reactions.

Before treatment with Rituxan, patients should tell their doctor if they have an infection, including one that will not go away or keeps coming back.

If patients experience any symptoms or side effects during or after Rituxan treatment, they should seek immediate medical attention.

For additional important safety information please see the Rituxan full Prescribing Information, including BOXED WARNINGS and Medication Guide.

Access to Treatment

At Genentech, we strongly believe that Rituxan^® (rituximab) should be accessible to the people who need it. That’s why we offer 3 important programs that offer various types of financial assistance:

Rituxan for RA Experience Program—provides eligible patients with up to $4000 a year in co-pay relief. For more information, call 1-877-474-8892 or visit Rituxan.tmgcard.com.

Genentech Rheumatology Access Solutions^™ —designed to help patients resolve their insurance coverage and reimbursement issues. For more information, call 1-877-474-8892 or visit GenentechAccessSolutions.com.

Genentech^® Access to Care Foundation (GATCF)—helps patients who are uninsured or denied coverage obtain treatment if they meet certain medical and financial criteria. For more information, call 1-800-530-3083 or visit www.Gene.com.