Below you'll find some common questions that people have about granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) and Rituxan. Click any of the questions you're curious about to see the answer.
GPA and MPA are two types of ANCA-associated vasculitis (AAV). AAV is a form of vasculitis that primarily affects the small- and medium-sized blood vessels in your body. In general, GPA and MPA affect the sinuses, kidneys, lungs, and skin, but the way the diseases show themselves varies. Learn what to look for on our GPA and MPA signs and symptoms page
ANCA=antineutrophil cytoplasmic antibody.
When starting a treatment, there are many important factors to discuss with your doctor, including the potential risks and benefits. The FDA-approved Rituxan safety information includes the risk of some potentially serious and life-threatening side effects. To learn more about the possible side effects of Rituxan, please see the Important Side Effect Information page.
If your health insurance plan will not cover Rituxan, you and your doctor’s office can file an appeal. Contact your doctor to ask if you should file an appeal. We have resources to help you and your doctor file one. To learn more about your potential financial assistance options, visit our financial assistance page.
Our patient resource center is dedicated to getting patients and caregivers to the right resources. Call 1-877-GENENTECH (1-877-436-3683) Monday-Friday, 6 AM-5 PM PT with questions.
Rituxan must be given directly into the bloodstream in order for it to be effective. So instead of being taken as a pill or an injection, it is given as an infusion, which is a needle placed in a vein by a healthcare professional. Infusions are a relatively common form of treatment used for a variety of conditions. Infusions are given by a trained healthcare professional who is there with you to help manage the process and monitor for reactions. Rituxan will be given at your doctor's or nurse practitioner’s office, an infusion center, or a hospital. Each infusion typically lasts 3 to 5 hours, so it’s a good idea to plan accordingly.
You may be given additional medicine before each infusion to reduce the risk of side effects (this will add to the total time of your treatment). If you experience any discomfort during the infusion, seek immediate medical attention.
Infusion-related reactions are the most common side effect of Rituxan treatment. Serious infusion-related reactions can happen during your infusion or within 24 hours after your infusion of Rituxan.
Rituxan is given as an intravenous (IV) infusion once weekly for 4 weeks to induce remission if you have active GPA or MPA.
The dosing for Rituxan is slightly different if your GPA or MPA is already under control. Your doctor may start by giving 2 IV infusions, 2 weeks apart. After that, you will receive a single IV infusion every 6 months or based on your doctor's evaluation of your symptoms.
*Genentech Access Solutions cannot complete or submit an appeal for you
The information contained in this section of the site is intended for U.S. healthcare professionals only. Click "OK" if you are a healthcare professional.
The link you have selected will take you away from this site to one that is not owned or controlled by Genentech, Inc. Genentech, Inc. makes no representation as to the accuracy of the information contained on sites we do not own or control. Genentech does not recommend and does not endorse the content on any third-party websites. Your use of third-party websites is at your own risk and subject to the terms and conditions of use for such sites.